Version history

{
  "scope": "mouse retrosplenial cortex; contextual fear memory",
  "claim_text": "Optogenetic high-frequency reactivation of fear-memory ensembles in mouse retrosplenial cortex one day after learning produces features of remote-memory consolidation, but only when reactivation occurs during sleep or anesthesia.",
  "raw_fields": {
    "n": null,
    "doi": "10.1073/pnas.1818432116",
    "claim": "Optogenetic high-frequency reactivation of fear-memory ensembles in mouse retrosplenial cortex one day after learning produces features of remote-memory consolidation, but only when reactivation occurs during sleep or anesthesia.",
    "cite_key": "DeSousa2019",
    "evidence": "TRAP-tagged ensemble optogenetic stimulation in mouse RSC; behavioral assays of memory generalization and hippocampal dependence.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse retrosplenial cortex; contextual fear memory",
    "argument_role": "supporting",
    "replication_status": "within_lab_replication",
    "claim_source_sentence": "High-frequency stimulation of these ensembles in the retrosplenial cortex 1 day after learning produced a recent memory with features normally observed in consolidated remote memories, including higher engagement of neocortical areas during retrieval, contextual generalization, and decreased hippocampal dependence.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/s41467-021-21471-2"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_11_evidence_package.json",
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  "review_repo": "ComputationalReviewRecurrence",
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  "source_span": "High-frequency stimulation of these ensembles in the retrosplenial cortex 1 day after learning produced a recent memory with features normally observed in consolidated remote memories, including higher engagement of neocortical areas during retrieval, contextual generalization, and decreased hippocampal dependence.",
  "study_system": "mouse retrosplenial cortex; contextual fear memory",
  "evidence_refs": [
    {
      "ref": "paper:paper-a3fbc6b44c2b"
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  "section_title": "11. Physiological signature III — pattern completion, replay, and sequence generation as recurrent-circuit read-outs in mouse cortex",
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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  "evidence_summary": "TRAP-tagged ensemble optogenetic stimulation in mouse RSC; behavioral assays of memory generalization and hippocampal dependence.",
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  "replication_status": "within_lab_replication",
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  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}