Version history

{
  "scope": "mouse cortical interneurons and pyramidal neurons at 37°C",
  "claim_text": "Fast-spiking GABAergic neurons have twice as much sodium entry during action potentials as the theoretical minimum, compared to only ~25% excess in pyramidal neurons, because sodium channel inactivation is incomplete during the narrow spike falling phase.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2009.12.011",
    "claim": "Fast-spiking GABAergic neurons have twice as much sodium entry during action potentials as the theoretical minimum, compared to only ~25% excess in pyramidal neurons, because sodium channel inactivation is incomplete during the narrow spike falling phase.",
    "evidence": "Measured sodium entry time course during APs at 37°C in mouse central neurons. The narrow spikes of FS neurons result in incomplete sodium channel inactivation, reducing metabolic efficiency but enhancing high-frequency firing ability.",
    "effect_size": "2x theoretical minimum sodium entry in FS neurons vs 1.25x in pyramidal neurons",
    "text_access": "fulltext",
    "study_system": "mouse cortical interneurons and pyramidal neurons at 37°C",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "In fast-spiking GABAergic neurons (cerebellar Purkinje cells and cortical interneurons), twice as much sodium enters as the theoretical minimum. The extra entry occurs because sodium channel inactivation is incomplete during the falling phase of the spike.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2018.02.024"
    ],
    "effect_size_source_sentence": "only ~25% more sodium enters than the theoretical minimum necessary for spike depolarization... in fast-spiking GABAergic neurons, twice as much sodium enters as the theoretical minimum."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "2x theoretical minimum sodium entry in FS neurons vs 1.25x in pyramidal neurons",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-5913a3633195"
  ],
  "source_span": "In fast-spiking GABAergic neurons (cerebellar Purkinje cells and cortical interneurons), twice as much sodium enters as the theoretical minimum. The extra entry occurs because sodium channel inactivation is incomplete during the falling phase of the spike.",
  "study_system": "mouse cortical interneurons and pyramidal neurons at 37°C",
  "evidence_refs": [
    {
      "ref": "paper:paper-5913a3633195"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Measured sodium entry time course during APs at 37°C in mouse central neurons. The narrow spikes of FS neurons result in incomplete sodium channel inactivation, reducing metabolic efficiency but enhancing high-frequency firing ability.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}