Version history

{
  "scope": "basal-ganglia",
  "claim_text": "Optogenetic photostimulation of channelrhodopsin-2-expressing hypocretin/orexin neurons in the lateral hypothalamus increases the probability of transitions from slow wave or REM sleep to wakefulness in freely moving mice, with 5–30 Hz trains reducing latency to wake while 1 Hz trains do not — establishing a frequency-dependent causal role of Hcrt neurons in arousal.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature06310",
    "claim": "Optogenetic photostimulation of channelrhodopsin-2-expressing hypocretin/orexin neurons in the lateral hypothalamus increases the probability of transitions from slow wave or REM sleep to wakefulness in freely moving mice, with 5–30 Hz trains reducing latency to wake while 1 Hz trains do not — establishing a frequency-dependent causal role of Hcrt neurons in arousal.",
    "cite_key": "Adamantidis2007",
    "evidence": "abstract_only",
    "effect_size": null,
    "text_access": "abstract",
    "study_system": null,
    "source_cluster_id": "cluster_08",
    "replication_status": "unreplicated",
    "claim_source_sentence": "The neural underpinnings of sleep involve interactions between sleep-promoting areas such as the anterior hypothalamus, and arousal systems located in the posterior hypothalamus, the basal forebrain and the brainstem.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_09_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
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  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
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    "paper:33ec7ac1-f3ee-4b0d-9f96-765915588694"
  ],
  "source_span": "The neural underpinnings of sleep involve interactions between sleep-promoting areas such as the anterior hypothalamus, and arousal systems located in the posterior hypothalamus, the basal forebrain and the brainstem.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:33ec7ac1-f3ee-4b0d-9f96-765915588694"
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  "section_title": "The Hypothalamic Extension: Loops for Motivated Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
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  "evidence_summary": "abstract_only",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "unreplicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-09",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_09_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}