Version history

{
  "scope": "mouse cortical GABAergic neurons",
  "claim_text": "Fast-spiking PV basket cells express the highest levels and diversity of Nav and Kv channels among GABAergic neurons, including multiple Navs (Scn9a, Scn8a, Scn1a, Scn3a) that underlie fast signaling.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.cell.2017.08.032",
    "claim": "Fast-spiking PV basket cells express the highest levels and diversity of Nav and Kv channels among GABAergic neurons, including multiple Navs (Scn9a, Scn8a, Scn1a, Scn3a) that underlie fast signaling.",
    "evidence": "Computational genomic screen of transcriptional profiles from physiologically characterized cortical GABAergic neurons identified ~40 gene families across 6 categories defining cardinal neuron types.",
    "effect_size": "~40 gene families across 6 categories; PV cells enriched in Scn9a, Scn8a, Scn1a, Scn3a, Scn1b, Scn4b, Scn2b",
    "text_access": "fulltext",
    "study_system": "mouse cortical GABAergic neurons",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The prominent enrichment of multiple Navs (Scn9a, Scn8a, Scn1a, Scn3a, Scn1b, Scn4b, Scn2b) likely underlie the 'supercritical density' of Nav for ensuring fast signaling in PV cell axons, and the striking elevation of a large set of fast-kinetics Kv1-4 members may implement rapid repolarization.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.0105-09.2009"
    ],
    "effect_size_source_sentence": "Fast-spiking PV basket cells express the highest levels and diversity of Nav channels."
  },
  "section_id": "section_02_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "effect_size": "~40 gene families across 6 categories; PV cells enriched in Scn9a, Scn8a, Scn1a, Scn3a, Scn1b, Scn4b, Scn2b",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-35a6c66c3e2e"
  ],
  "source_span": "The prominent enrichment of multiple Navs (Scn9a, Scn8a, Scn1a, Scn3a, Scn1b, Scn4b, Scn2b) likely underlie the 'supercritical density' of Nav for ensuring fast signaling in PV cell axons, and the striking elevation of a large set of fast-kinetics Kv1-4 members may implement rapid repolarization.",
  "study_system": "mouse cortical GABAergic neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-35a6c66c3e2e"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Computational genomic screen of transcriptional profiles from physiologically characterized cortical GABAergic neurons identified ~40 gene families across 6 categories defining cardinal neuron types.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}