Version history

{
  "scope": "vip-interneurons",
  "claim_text": "In auditory cortex L1 interneurons (a CGE-derived/VIP-related population) gate the tonotopic critical period via cholinergic (nicotinic) input; developmental upregulation of the nicotinic-modulator Lynx1 closes the period, and overriding Lynx1 keeps it open — providing a molecular handle by which neuromodulation controls plasticity.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41593-017-0064-2",
    "year": "2018",
    "claim": "In auditory cortex L1 interneurons (a CGE-derived/VIP-related population) gate the tonotopic critical period via cholinergic (nicotinic) input; developmental upregulation of the nicotinic-modulator Lynx1 closes the period, and overriding Lynx1 keeps it open — providing a molecular handle by which neuromodulation controls plasticity.",
    "title": "Inhibitory circuit gating of auditory critical-period plasticity",
    "journal": "",
    "species": "mouse",
    "cite_key": "Takesian2018",
    "evidence": "Optogenetics + cell-type-specific silencing + Lynx1 manipulation in mouse A1.",
    "effect_size": "Silencing L1 cells abolished critical-period plasticity; Lynx1 overexpression closed it; loss of Lynx1 kept it open.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "single_study",
    "_source_cluster_index": 36,
    "claim_source_sentence": "Developmental transitions of nicotinic acetylcholine receptor (nAChR) sensitivity in these cells by the Lynx1 protein can be overridden to extend critical period closure.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Silencing L1 (but not VIP) cells abolishes map plasticity during the tonotopic critical period."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "Silencing L1 cells abolished critical-period plasticity; Lynx1 overexpression closed it; loss of Lynx1 kept it open.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-da0cfdd6fe54"
  ],
  "source_span": "Developmental transitions of nicotinic acetylcholine receptor (nAChR) sensitivity in these cells by the Lynx1 protein can be overridden to extend critical period closure.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-da0cfdd6fe54"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetics + cell-type-specific silencing + Lynx1 manipulation in mouse A1.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}