In mouse primary visual cortex, selective glutamate-receptor blockade of somato…

In mouse primary visual cortex, selective glutamate-receptor blockade of somatostatin (SST) interneurons reveals a paradoxical facilitation of their activity (the hallmark of inhibition stabilization) that grows with increasing stimulus contrast and arousal; a circuit model shows that strong sensory input and high arousal shift the network into a regime where SST cells (rather than other interneuron classes) are necessary to maintain network stability — direct dynamic evidence for input- and state-dependent ISN operation.

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  "n": 0,
  "doi": "10.1016/j.celrep.2025.115954",
  "claim": "In mouse primary visual cortex, selective glutamate-receptor blockade of somatostatin (SST) interneurons reveals a paradoxical facilitation of their activity (the hallmark of inhibition stabilization) that grows with increasing stimulus contrast and arousal; a circuit model shows that strong sensory input and high arousal shift the network into a regime where SST cells (rather than other interneuron classes) are necessary to maintain network stability — direct dynamic evidence for input- and state-dependent ISN operation.",
  "cite_key": "Cammarata2025",
  "evidence": "In a computational model of the visual cortex circuit, increasing sensory input and arousal both move the network toward a regime where other classes of interneurons are no longer sufficient for maintaining network stability.",
  "effect_size": "",
  "text_access": "fulltext",
  "study_system": "mouse primary visual cortex; cell-type-specific glutamate-receptor blockade of SST interneurons + simultaneous electrophysiology and computational modeling across arousal/contrast states",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "Antagonizing this key input for the recruitment of SST cells drives a paradoxical facilitation of their activity-the hallmark of inhibition stabilization-with increasing stimulus contrast, and even more so with high arousal.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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