In adult mice on a memory-guided behavior, mPFC working-memory population codin…

In adult mice on a memory-guided behavior, mPFC working-memory population coding is concurrently modality-dependent and crossmodal; with middle age, crossmodal coding diminishes while modality-dependent coding persists, resting-state functional connectivity among memory-coding neurons decreases, and optogenetic inactivation reveals heightened vulnerability of mPFC delay-period activity to perturbation — linking age-related decline of working memory to weakening of recurrent connectivity supporting persistent activity.

{
  "n": 0,
  "doi": "10.1038/s41467-023-43142-0",
  "claim": "In adult mice on a memory-guided behavior, mPFC working-memory population coding is concurrently modality-dependent and crossmodal; with middle age, crossmodal coding diminishes while modality-dependent coding persists, resting-state functional connectivity among memory-coding neurons decreases, and optogenetic inactivation reveals heightened vulnerability of mPFC delay-period activity to perturbation — linking age-related decline of working memory to weakening of recurrent connectivity supporting persistent activity.",
  "cite_key": "Chong2023",
  "evidence": "Population activity in the young adult mPFC exhibits dissociable yet overlapping patterns between tactile and auditory modalities, enabling crossmodal memory coding concurrent with modality-dependent coding. In middle age, however, crossmodal coding remarkably diminishes while modality-dependent coding persists, and both types of coding decay in advanced age. Optogenetic inactivation reveals that the middle-aged mPFC exhibits heightened vulnerability to perturbations.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse medial prefrontal cortex across age (young adult → middle-aged → advanced); two-photon calcium imaging + optogenetic inactivation in a crossmodal working-memory task",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "Resting-state functional connectivity, especially among memory-coding neurons, decreases already in middle age, suggesting deteriorated recurrent circuits for memory maintenance.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-053e4e126ed2"
]

[
  {
    "ref": "paper:paper-053e4e126ed2"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

Population activity in the young adult mPFC exhibits dissociable yet overlapping patterns between tactile and auditory modalities, enabling crossmodal memory coding concurrent with modality-dependent coding. In middle age, however, crossmodal coding remarkably diminishes while modality-dependent coding persists, and both types of coding decay in advanced age. Optogenetic inactivation reveals that the middle-aged mPFC exhibits heightened vulnerability to perturbations.