- claim_text
Dynamic Behavioral and Molecular Changes Induced by Chronic Restraint Stress Exposure in Mice — Chronic stress is a major risk factor contributing to cellular changes in the brain that precipitate the emergence of various behavioral changes, including anxi
- raw_fields
{
"n": 6,
"doi": "10.3390/ijms27010167",
"claim": "Dynamic Behavioral and Molecular Changes Induced by Chronic Restraint Stress Exposure in Mice — Chronic stress is a major risk factor contributing to cellular changes in the brain that precipitate the emergence of various behavioral changes, including anxi",
"title": null,
"cite_key": "Prevot2025",
"evidence": "Reported in International journal of molecular sciences (2025); from Body of abstract.",
"effect_size": "6",
"text_access": "abstract_only",
"study_system": "mouse",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "replication_unknown",
"_source_cluster_index": 314,
"claim_source_sentence": "Chronic stress is a major risk factor contributing to cellular changes in the brain that precipitate the emergence of various behavioral changes, including anxiety and anhedonia-symptoms relevant to mood disorders including major depression-however the sequence and trajectory of early molecular changes is poorly characterized.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Using the chronic restraint stress (CRS) model in mice (N = 6-8/sex/group), we assessed the impact of 0, 7, 14, 21, 28, or 35 days of CRS at the behavioral level on the emergence of anxiety-like and anhedonia-like phenotypes."
}- source_refs
[
"paper:paper-b0fa400d4289"
]
- source_span
Chronic stress is a major risk factor contributing to cellular changes in the brain that precipitate the emergence of various behavioral changes, including anxiety and anhedonia-symptoms relevant to mood disorders including major depression-however the sequence and trajectory of early molecular changes is poorly characterized.
- evidence_refs
[
{
"ref": "paper:paper-b0fa400d4289"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}