- claim_text
Both direct (striatonigral) and indirect (striatopallidal) pathways are necessary for smooth initiation and execution of learned action sequences — striatonigral perturbation slows initiation while striatopallidal perturbation aborts ongoing performance.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.cell.2016.06.032",
"claim": "Both direct (striatonigral) and indirect (striatopallidal) pathways are necessary for smooth initiation and execution of learned action sequences — striatonigral perturbation slows initiation while striatopallidal perturbation aborts ongoing performance.",
"cite_key": "Tecuapetla2016",
"evidence": "",
"effect_size": "striatonigral perturbation slows initiation; striatopallidal perturbation aborts initiation",
"text_access": "abstract_only",
"study_system": "mice, optogenetic state-dependent manipulation, operant action sequence task",
"source_cluster_id": "cluster_04",
"replication_status": "replicated",
"claim_source_sentence": "Optogenetic inhibition or stimulation of each pathway before sequence initiation increased the latency for initiation: manipulations of the striatonigral pathway activity slowed action initiation, and those of the striatopallidal pathway aborted action initiation.",
"replication_evidence_dois": [
"10.1038/nature11846",
"10.1038/nature17639"
],
"effect_size_source_sentence": "Optogenetic inhibition or stimulation of each pathway before sequence initiation increased the latency for initiation: manipulations of the striatonigral pathway activity slowed action initiation, and those of the striatopallidal pathway aborted action initiation."
}- source_refs
[
"paper:paper-10_1016_j_cell_2016_06_032"
]
- source_span
Optogenetic inhibition or stimulation of each pathway before sequence initiation increased the latency for initiation: manipulations of the striatonigral pathway activity slowed action initiation, and those of the striatopallidal pathway aborted action initiation.
- evidence_refs
[
{
"ref": "paper:paper-10_1016_j_cell_2016_06_032"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}