- claim_text
Recent fluorescence imaging advances allow observation of the dynamics of thousands of individual neurons across multiple brain areas for extended durations in awake behaving mammals, with calcium imaging providing area-interaction tracking at cellular resolution and high-speed voltage imaging revealing spiking patterns of targeted cell types.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.cell.2021.12.007",
"claim": "Recent fluorescence imaging advances allow observation of the dynamics of thousands of individual neurons across multiple brain areas for extended durations in awake behaving mammals, with calcium imaging providing area-interaction tracking at cellular resolution and high-speed voltage imaging revealing spiking patterns of targeted cell types.",
"cite_key": "Kim2022",
"evidence": "Comprehensive review framing the methodological landscape of mouse-cortex imaging and its limits.",
"effect_size": null,
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"study_system": "Fluorescence imaging (calcium and voltage) across awake behaving mammals, primarily mouse cortex",
"argument_role": "supporting",
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"claim_source_sentence": "Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of thousands of individual neurons, identified genetically or by their connectivity, across multiple brain areas and for extended durations in awake behaving mammals.",
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}- source_refs
[
"paper:paper-89a449ba5293"
]
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Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of thousands of individual neurons, identified genetically or by their connectivity, across multiple brain areas and for extended durations in awake behaving mammals.
- evidence_refs
[
{
"ref": "paper:paper-89a449ba5293"
}
]- section_title
15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon
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{
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"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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