Quantitative double-immunolabeling across mouse cortex established that parvalb…

Quantitative double-immunolabeling across mouse cortex established that parvalbumin, somatostatin, and VIP identify three reliably non-overlapping inhibitory subpopulations, while CR and NPY overlap substantially with SST (~21.6% and ~7.1% of SST+ cells respectively) — formalizing the canonical PV/SST/VIP partition in mouse but flagging marker promiscuity for CR.

{
  "n": null,
  "doi": "10.1002/cne.22229",
  "claim": "Quantitative double-immunolabeling across mouse cortex established that parvalbumin, somatostatin, and VIP identify three reliably non-overlapping inhibitory subpopulations, while CR and NPY overlap substantially with SST (~21.6% and ~7.1% of SST+ cells respectively) — formalizing the canonical PV/SST/VIP partition in mouse but flagging marker promiscuity for CR.",
  "title": null,
  "cite_key": "Xu2010a",
  "evidence": "Double immunochemistry across mouse cortical regions; quantification of marker overlap across PV, SST, VIP, CR, NPY, CCK.",
  "effect_size": "SOM/CR overlap 21.6%; SOM/NPY 7.1%",
  "text_access": "abstract_only",
  "study_system": "mouse cortex multi-marker IHC",
  "target_section": "section_03",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "single_study",
  "_source_cluster_index": 60,
  "claim_source_sentence": "We found that, PV, SOM, and vasointenstinal peptide (VIP) reliably identify three nonoverlapping distinct subpopulations, as there was no overlap of immunoreactivity between PV and all the other chemical markers tested, and SOM and VIP did not show any overlap in labeled neurons in all the cortical areas."
}

[
  "paper:paper-f74768c3fc02"
]

We found that, PV, SOM, and vasointenstinal peptide (VIP) reliably identify three nonoverlapping distinct subpopulations, as there was no overlap of immunoreactivity between PV and all the other chemical markers tested, and SOM and VIP did not show any overlap in labeled neurons in all the cortical areas.

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    "ref": "paper:paper-f74768c3fc02"
  }
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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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