Version history

{
  "scope": "vip-interneurons",
  "claim_text": "In a mouse model of Dravet syndrome (Scn1a+/−) the irregular-spiking subtype of VIP interneurons shows impaired excitability that is rescued by Nav1.1-specific toxin Hm1a; the IS-vs-CA firing pattern of VIP cells is set by KCNQ M-current and switches to tonic firing on muscarinic receptor activation, demonstrating peptidergic/muscarinic modulation of VIP firing in disease-relevant circuits.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.46846",
    "year": "2019",
    "claim": "In a mouse model of Dravet syndrome (Scn1a+/−) the irregular-spiking subtype of VIP interneurons shows impaired excitability that is rescued by Nav1.1-specific toxin Hm1a; the IS-vs-CA firing pattern of VIP cells is set by KCNQ M-current and switches to tonic firing on muscarinic receptor activation, demonstrating peptidergic/muscarinic modulation of VIP firing in disease-relevant circuits.",
    "title": "Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome",
    "journal": "",
    "species": "mouse",
    "cite_key": "Goff2019",
    "evidence": "Whole-cell recordings in Scn1a+/− vs. WT slices + pharmacology.",
    "effect_size": "Hm1a rescued IS firing; muscarinic activation converted IS to CA firing.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "single_study",
    "_source_cluster_index": 35,
    "claim_source_sentence": "IS VIP-INs switched to tonic firing with both pharmacologic blockade of M-current and muscarinic acetylcholine receptor activation.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Application of the Nav1.1-specific toxin Hm1a rescued the observed deficits."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "Hm1a rescued IS firing; muscarinic activation converted IS to CA firing.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-038d4952015c"
  ],
  "source_span": "IS VIP-INs switched to tonic firing with both pharmacologic blockade of M-current and muscarinic acetylcholine receptor activation.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-038d4952015c"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Whole-cell recordings in Scn1a+/− vs. WT slices + pharmacology.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}