Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cogniti…

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scope: epilepsy/Scn1a models
claim_text: Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease
section_id: section_11_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
effect_size: Network dysrhythmias in AD and multiple neuropsychiatric disorders are associated with hypofunction of Nav1
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-11
source_kind: review_finding
source_path: evidence/section_11_evidence_package.json
source_span: Inhibitory interneurons regulate the oscillatory rhythms and network synchrony that are required for cognitive functions and disrupted in Alzheimer's disease (AD).
study_system: epilepsy/Scn1a models
section_title: Species Translation, Human Data, and Disease Models
evidence_summary: Study on PV interneurons in epilepsy/Dravet
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-11
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.neuron.2018.02.029",
  "claim": "Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease",
  "evidence": "Study on PV interneurons in epilepsy/Dravet",
  "effect_size": "Network dysrhythmias in AD and multiple neuropsychiatric disorders are associated with hypofunction of Nav1",
  "text_access": "abstract_only",
  "study_system": "epilepsy/Scn1a models",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Inhibitory interneurons regulate the oscillatory rhythms and network synchrony that are required for cognitive functions and disrupted in Alzheimer's disease (AD).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Network dysrhythmias in AD and multiple neuropsychiatric disorders are associated with hypofunction of Nav1."
}

source_refs

[
  "paper:paper-97c54b332720"
]

evidence_refs

[
  {
    "ref": "paper:paper-97c54b332720"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cogniti…

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Replication

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