Version history

{
  "scope": "human + rat cortex; paired patch-clamp",
  "claim_text": "Group I mGluR activation by DHPG enhanced excitatory synaptic transmission in 54% of fast-spiking interneurons but only 15% of non-fast-spiking interneurons in human supragranular cortex (paired patch-clamp, neurosurgical slices), with conservation between human and rodent for fast-spiking interneurons but species-specific paired-pulse-ratio differences—direct functional evidence for cell-type-specific group-I mGluR modulation in human cortex.",
  "raw_fields": {
    "n": null,
    "doi": "10.3389/fnsyn.2026.1766413",
    "claim": "Group I mGluR activation by DHPG enhanced excitatory synaptic transmission in 54% of fast-spiking interneurons but only 15% of non-fast-spiking interneurons in human supragranular cortex (paired patch-clamp, neurosurgical slices), with conservation between human and rodent for fast-spiking interneurons but species-specific paired-pulse-ratio differences—direct functional evidence for cell-type-specific group-I mGluR modulation in human cortex.",
    "title": null,
    "cite_key": "Sandle2026",
    "evidence": "Paired whole-cell patch-clamp recordings of synaptically connected pyramidal-to-interneuron pairs in human neocortical slices (neurosurgical specimens); DHPG pharmacology; rat comparison.",
    "effect_size": "54% FS vs 15% nFS interneurons showed EPSC enhancement",
    "text_access": "abstract_only",
    "study_system": "human + rat cortex; paired patch-clamp",
    "target_section": "section_05",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replication_supported",
    "_source_cluster_index": 102,
    "claim_source_sentence": "Specifically, we observed acute enhancement of excitatory postsynaptic current (EPSC) amplitudes in 54% of fast-spiking interneurons and in 15% of non-fast-spiking interneuron types. Applying the same experimental protocol in slices from Wistar rats resulted in a similar increase in synaptic strength in fast-spiking interneurons. However, paired-pulse ratio analysis showed species-dependent differences.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "we observed acute enhancement of excitatory postsynaptic current (EPSC) amplitudes in 54% of fast-spiking interneurons and in 15% of non-fast-spiking interneuron types"
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": "54% FS vs 15% nFS interneurons showed EPSC enhancement",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-9af6e0492426"
  ],
  "source_span": "Specifically, we observed acute enhancement of excitatory postsynaptic current (EPSC) amplitudes in 54% of fast-spiking interneurons and in 15% of non-fast-spiking interneuron types. Applying the same experimental protocol in slices from Wistar rats resulted in a similar increase in synaptic strength in fast-spiking interneurons. However, paired-pulse ratio analysis showed species-dependent differences.",
  "study_system": "human + rat cortex; paired patch-clamp",
  "evidence_refs": [
    {
      "ref": "paper:paper-9af6e0492426"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Paired whole-cell patch-clamp recordings of synaptically connected pyramidal-to-interneuron pairs in human neocortical slices (neurosurgical specimens); DHPG pharmacology; rat comparison.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_supported",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}