- raw_fields
{
"n": null,
"doi": "10.7554/elife.55130",
"claim": "VIP neurons in mouse V1 respond strongly to low contrast front-to-back motion that is congruent with self-motion during locomotion but are suppressed by other directions and contrasts.",
"cite_key": "Millman2020",
"evidence": "Vasoactive intestinal peptide-expressing (VIP) interneurons in the cortex regulate feedback inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) interneurons and, reciprocally, SST neurons inhibit VIP neurons. Although VIP neuron activity in the primary visual cortex (V1) of mouse is highly correlated with locomotion, the relevance of locomotion-related VIP neuron activity to visual coding is not known. Here we show that VIP neurons in mouse V1 respond strongly to...",
"effect_size": "Virtually all VIP neurons responded only at low (<20%) contrast to front-to-back motion (0 degrees; nasal-to-temporal) or an adjacent direction (), yielding the greatest direction bias among Cre lines as quantified by the vector sum of direction preferences ().",
"text_access": "fulltext",
"study_system": "mouse; V1, visual cortex; computational model; eLife",
"argument_role": "supporting",
"replication_status": "single_study",
"claim_source_sentence": "Here we show that VIP neurons in mouse V1 respond strongly to low contrast front-to-back motion that is congruent with self-motion during locomotion but are suppressed by other directions and contrasts.",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"claim_rewritten_from_source": true,
"effect_size_source_sentence": "Virtually all VIP neurons responded only at low (<20%) contrast to front-to-back motion (0 degrees; nasal-to-temporal) or an adjacent direction (), yielding the greatest direction bias among Cre lines as quantified by the vector sum of direction preferences ()."
}- effect_size
Virtually all VIP neurons responded only at low (<20%) contrast to front-to-back motion (0 degrees; nasal-to-temporal) or an adjacent direction (), yielding the greatest direction bias among Cre lines as quantified by the vector sum of direction preferences ().
- source_refs
[
"paper:paper-f2c584233c97"
]
- evidence_refs
[
{
"ref": "paper:paper-f2c584233c97"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Vasoactive intestinal peptide-expressing (VIP) interneurons in the cortex regulate feedback inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) interneurons and, reciprocally, SST neurons inhibit VIP neurons. Although VIP neuron activity in the primary visual cortex (V1) of mouse is highly correlated with locomotion, the relevance of locomotion-related VIP neuron activity to visual coding is not known. Here we show that VIP neurons in mouse V1 respond strongly to...