- claim_text
Holographic two-photon optogenetic perturbations in mouse hypothalamus provide causal evidence that an identified population of neurons implements a line attractor: on-manifold pulses are integrated, off-manifold perturbations rapidly relax.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41586-024-07915-x",
"claim": "Holographic two-photon optogenetic perturbations in mouse hypothalamus provide causal evidence that an identified population of neurons implements a line attractor: on-manifold pulses are integrated, off-manifold perturbations rapidly relax.",
"cite_key": "Vinograd2024",
"evidence": "Two-photon calcium imaging combined with holographic optogenetic stimulation of identified line-attractor-contributing neurons in male mice; observed manifold-dependent relaxation/integration kinetics.",
"effect_size": "qualitative",
"text_access": "abstract_only",
"study_system": "mouse hypothalamus (VMH ventromedial hypothalamus) line-attractor population",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "On-manifold perturbations yielded integration of optogenetic stimulation pulses and persistent activity that drove the system along the line attractor, while transient off-manifold perturbations were followed by rapid relaxation back into the attractor.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1038/s41586-022-05377-7"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-e16a5a4b449d"
]
- source_span
On-manifold perturbations yielded integration of optogenetic stimulation pulses and persistent activity that drove the system along the line attractor, while transient off-manifold perturbations were followed by rapid relaxation back into the attractor.
- evidence_refs
[
{
"ref": "paper:paper-e16a5a4b449d"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}