- claim_text
Single-cell two-photon optogenetic activation of individual VIP interneurons in mouse V1 in vivo creates spatially narrow, transient "holes" in the SST inhibitory blanket; VIP axons are narrow and target nearby SST cells, providing focal lateral disinhibition of pyramids.
- raw_fields
{
"n": null,
"doi": "10.1523/jneurosci.3646-15.2016",
"claim": "Single-cell two-photon optogenetic activation of individual VIP interneurons in mouse V1 in vivo creates spatially narrow, transient \"holes\" in the SST inhibitory blanket; VIP axons are narrow and target nearby SST cells, providing focal lateral disinhibition of pyramids.",
"title": null,
"cite_key": "Karnani2016b",
"evidence": "In vivo two-photon optogenetic activation of single VIP cells with simultaneous two-photon Ca2+ imaging.",
"effect_size": "qualitative spatial localization (narrow axons; focal disinhibition).",
"text_access": "abstract_only",
"study_system": "mouse V1 in vivo",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "independently_replicated",
"_source_cluster_index": 5,
"claim_source_sentence": "We find that VIP interneurons have narrow axons and inhibit nearby somatostatin interneurons, which themselves inhibit pyramidal cells. Moreover, via this lateral disinhibition, VIP cells in vivo make local and transient \"holes\" in the inhibitory blanket extended by SOM cells.",
"replication_evidence_dois": [
"10.1038/nn.3446",
"10.1126/science.1254126"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-0a3cf7627c63"
]
- source_span
We find that VIP interneurons have narrow axons and inhibit nearby somatostatin interneurons, which themselves inhibit pyramidal cells. Moreover, via this lateral disinhibition, VIP cells in vivo make local and transient "holes" in the inhibitory blanket extended by SOM cells.
- evidence_refs
[
{
"ref": "paper:paper-0a3cf7627c63"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}