Version history

{
  "scope": "rat, IL cortex, optogenetics + pharmacogenetics",
  "claim_text": "Ventral hippocampal projections recruit PV interneurons in IL cortex to mediate feed-forward inhibition and promote fear relapse",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41593-018-0073-9",
    "claim": "Ventral hippocampal projections recruit PV interneurons in IL cortex to mediate feed-forward inhibition and promote fear relapse",
    "evidence": "vHPC input to IL amygdala-projecting neurons dominated by feed-forward inhibition via PV cells; pharmacogenetic activation of vHPC-IL projections impaired extinction recall",
    "effect_size": "elimination of vHPC-mediated inhibition by PV silencing; impaired extinction recall",
    "text_access": "fulltext",
    "study_system": "rat, IL cortex, optogenetics + pharmacogenetics",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Selectively silencing parvalbumin-expressing, but not somatostatin-expressing, interneurons in the IL eliminated vHPC-mediated inhibition",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.1442-22.2023"
    ],
    "effect_size_source_sentence": "pharmacogenetic activation of vHPC→IL projections impaired extinction recall, whereas silencing IL projectors diminished fear renewal"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json",
  "effect_size": "elimination of vHPC-mediated inhibition by PV silencing; impaired extinction recall",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-08",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-14612dc2f89b"
  ],
  "source_span": "Selectively silencing parvalbumin-expressing, but not somatostatin-expressing, interneurons in the IL eliminated vHPC-mediated inhibition",
  "study_system": "rat, IL cortex, optogenetics + pharmacogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-14612dc2f89b"
    }
  ],
  "section_title": "In Vivo Dynamics and Behavioural Correlates",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "vHPC input to IL amygdala-projecting neurons dominated by feed-forward inhibition via PV cells; pharmacogenetic activation of vHPC-IL projections impaired extinction recall",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-08",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}