Version history

{
  "scope": "Multiple Cre-driver crosses with Rosa26-floxed-stop-fluorescent reporter knock-in mice",
  "claim_text": "The Ai14/Ai9 Cre-reporter knock-in mice (CAG-driven floxed-stop-tdTomato at the Rosa26 locus) display strong, ubiquitous tdTomato fluorescence on Cre-mediated excision sufficient to image fine dendrites and axonal projections.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nn.2467",
    "claim": "The Ai14/Ai9 Cre-reporter knock-in mice (CAG-driven floxed-stop-tdTomato at the Rosa26 locus) display strong, ubiquitous tdTomato fluorescence on Cre-mediated excision sufficient to image fine dendrites and axonal projections.",
    "cite_key": "Madisen2009",
    "evidence": "ISH/qPCR confirmed that Ai6, Ai9 and Ai14 produce strong fluorescent reporter expression compared with prior Rosa26 lines.",
    "effect_size": "14",
    "text_access": "fulltext",
    "study_system": "Multiple Cre-driver crosses with Rosa26-floxed-stop-fluorescent reporter knock-in mice",
    "source_cluster_id": "cluster_10",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The robust native fluorescence of these reporters enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo .",
    "replication_evidence_dois": [
      "10.1038/nn.3078",
      "10.1016/j.cell.2018.06.035"
    ],
    "effect_size_source_sentence": "The Ai14/Ai9 Cre-reporter knock-in mice (CAG-driven floxed-stop-tdTomato at the Rosa26 locus) display strong, ubiquitous tdTomato fluorescence on Cre-mediated excision sufficient to image fine dendrites and axonal projections."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": "14",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-20023653"
  ],
  "source_span": "The robust native fluorescence of these reporters enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo .",
  "study_system": "Multiple Cre-driver crosses with Rosa26-floxed-stop-fluorescent reporter knock-in mice",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-20023653"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "ISH/qPCR confirmed that Ai6, Ai9 and Ai14 produce strong fluorescent reporter expression compared with prior Rosa26 lines.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}