- claim_text
Conditional MeCP2 loss restricted to VIP interneurons recapitulates Rett-syndrome-like cortical dysfunction and behavioral deficits — demonstrating that VIP-IN MeCP2 is necessary for normal cortical circuit function and identifying VIP-INs as a key cellular substrate.
- raw_fields
{
"n": null,
"doi": "10.7554/elife.55639",
"claim": "Conditional MeCP2 loss restricted to VIP interneurons recapitulates Rett-syndrome-like cortical dysfunction and behavioral deficits — demonstrating that VIP-IN MeCP2 is necessary for normal cortical circuit function and identifying VIP-INs as a key cellular substrate.",
"title": null,
"cite_key": "Mossner2020",
"evidence": "Conditional Mecp2 KO in VIP-Cre mice + ephys + behavior in mouse cortex.",
"effect_size": null,
"text_access": "fulltext",
"study_system": "mouse cortex; conditional MeCP2 KO",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "single-study",
"_source_cluster_index": 70,
"claim_source_sentence": "Recent work has suggested that vasoactive intestinal peptide-expressing (VIP) interneurons may play a critical role in the proper development and function of cortical circuits.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-4effa559f79e"
]
- evidence_refs
[
{
"ref": "paper:paper-4effa559f79e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}