- claim_text
Randomized trial in 156 patients with advanced Parkinson's disease showed STN/GPi neurostimulation produced significantly greater improvements at 6 months in quality of life (PDQ-39 +9.5 points) and motor symptoms (UPDRS-III +19.6 points) than medical management.
- raw_fields
{
"n": 156,
"doi": "10.1056/nejmoa060281",
"claim": "Randomized trial in 156 patients with advanced Parkinson's disease showed STN/GPi neurostimulation produced significantly greater improvements at 6 months in quality of life (PDQ-39 +9.5 points) and motor symptoms (UPDRS-III +19.6 points) than medical management.",
"cite_key": "Deuschl2006",
"evidence": "",
"effect_size": "PDQ-39 mean Δ +9.5 points; UPDRS-III mean Δ +19.6 points; P<0.001",
"text_access": "abstract_only",
"study_system": "humans, randomized-pairs trial of bilateral STN/GPi DBS vs medical management for PD",
"source_cluster_id": "cluster_04",
"replication_status": "independently_replicated",
"claim_source_sentence": "Pairwise comparisons showed that neurostimulation, as compared with medication alone, caused greater improvements from baseline to six months in the PDQ-39 (50 of 78 pairs, P=0.02) and the UPDRS-III (55 of 78, P<0.001), with mean improvements of 9.5 and 19.6 points, respectively.",
"replication_evidence_dois": [
"10.1056/nejmoa000827"
],
"effect_size_source_sentence": "Pairwise comparisons showed that neurostimulation, as compared with medication alone, caused greater improvements from baseline to six months in the PDQ-39 (50 of 78 pairs, P=0.02) and the UPDRS-III (55 of 78, P<0.001), with mean improvements of 9.5 and 19.6 points, respectively."
}- source_refs
[
"paper:dfd3826d-d6d3-4889-921f-d6fa51b8e9b8"
]
- source_span
Pairwise comparisons showed that neurostimulation, as compared with medication alone, caused greater improvements from baseline to six months in the PDQ-39 (50 of 78 pairs, P=0.02) and the UPDRS-III (55 of 78, P<0.001), with mean improvements of 9.5 and 19.6 points, respectively.
- evidence_refs
[
{
"ref": "paper:dfd3826d-d6d3-4889-921f-d6fa51b8e9b8"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}