Across mouse visual cortex, large-scale Allen Brain Observatory recordings show…

Across mouse visual cortex, large-scale Allen Brain Observatory recordings show that visually evoked responses are weaker for more spatially predictable image patches and primarily reflect higher-level (not low-level) feature predictability, with stronger unpredictability sensitivity in superficial primary visual cortex — empirical support for predictive coding in mouse cortex independent of recent experience.

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  "n": 0,
  "doi": "10.1371/journal.pcbi.1013136",
  "claim": "Across mouse visual cortex, large-scale Allen Brain Observatory recordings show that visually evoked responses are weaker for more spatially predictable image patches and primarily reflect higher-level (not low-level) feature predictability, with stronger unpredictability sensitivity in superficial primary visual cortex — empirical support for predictive coding in mouse cortex independent of recent experience.",
  "cite_key": "Heilbron2026",
  "evidence": "Deep generative model + Allen Brain Observatory data; controlled for low-level tuning; superficial-layer asymmetry consistent with predictive coding.",
  "effect_size": "predictability effects strongest in superficial primary visual cortex; higher-level not low-level features",
  "text_access": "fulltext",
  "study_system": "Allen Brain Observatory, mouse visual cortex (multi-area Neuropixels)",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "First, cortical responses across the mouse visual system are shaped by sensory predictability, with more predictable image patches evoking weaker responses. Secondly, visual cortical neurons are primarily sensitive to the predictability of higher-level image features, even in neurons in the primary visual areas that are preferentially tuned to low-level visual features. Third, unpredictability sensitivity is stronger in the superficial layers of primary visual cortex, in line with predictive coding models.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "unpredictability sensitivity is stronger in the superficial layers of primary visual cortex, in line with predictive coding models."
}

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First, cortical responses across the mouse visual system are shaped by sensory predictability, with more predictable image patches evoking weaker responses. Secondly, visual cortical neurons are primarily sensitive to the predictability of higher-level image features, even in neurons in the primary visual areas that are preferentially tuned to low-level visual features. Third, unpredictability sensitivity is stronge...

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