In macaque, striatonigrostriatal projections form an ascending spiral in which…

In macaque, striatonigrostriatal projections form an ascending spiral in which ventromedial (limbic) striatum influences dorsolateral (motor) striatum via a hierarchy through ventral midbrain dopamine neurons, providing an anatomical limbic→cognitive→motor interface.

{
  "n": null,
  "doi": "10.1523/jneurosci.20-06-02369.2000",
  "claim": "In macaque, striatonigrostriatal projections form an ascending spiral in which ventromedial (limbic) striatum influences dorsolateral (motor) striatum via a hierarchy through ventral midbrain dopamine neurons, providing an anatomical limbic→cognitive→motor interface.",
  "cite_key": "Haber2000",
  "evidence": "Synthesis of retrograde and anterograde tracing experiments mapping striatonigrostriatal projections in macaque shell, core, central and dorsolateral striatum.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "macaque (synthesis of retrograde and anterograde tracing studies)",
  "source_cluster_id": "cluster_02",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Examination of results from multiple tracing experiments simultaneously demonstrates an interface between different striatal regions via the midbrain dopamine cells that forms an ascending spiral between regions.",
  "replication_evidence_dois": [
    "10.1152/jn.00270.2012",
    "10.1523/jneurosci.05-03-00776.1985"
  ],
  "effect_size_source_sentence": null
}

[
  "paper:paper-788157617fc0"
]

[
  {
    "ref": "paper:paper-788157617fc0"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}