Version history

{
  "scope": "mouse V1 L2/3 pyramidal neurons, in vivo two-photon + ex vivo paired recording, juvenile vs mature",
  "claim_text": "In mouse V1 L2/3, connection probability between pyramidal neurons increases steeply with their signal correlation only after eye opening (P22–26 vs P13–15), showing that functionally specific recurrent excitatory connectivity emerges with visual experience and is not present at eye-opening.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature12015",
    "claim": "In mouse V1 L2/3, connection probability between pyramidal neurons increases steeply with their signal correlation only after eye opening (P22–26 vs P13–15), showing that functionally specific recurrent excitatory connectivity emerges with visual experience and is not present at eye-opening.",
    "cite_key": "Ko2013",
    "evidence": "In vivo two-photon calcium imaging of L2/3 pyramidal responses to gratings at P13–15 and P22–26, followed by multi-electrode patch-clamp paired recordings of the same imaged cells in acute V1 slices; quantification of connection probability vs signal correlation and vs preferred-orientation difference.",
    "effect_size": "Significant connection-probability increase with signal correlation at P22–26 (P=4.6×10⁻⁵); not present at P13–15",
    "text_access": "fulltext",
    "study_system": "mouse V1 L2/3 pyramidal neurons, in vivo two-photon + ex vivo paired recording, juvenile vs mature",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "As we reported previously, among responsive L2/3 pyramidal cells, the connection probability increased steeply with increasing signal correlation at P22 – 26.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/nature09880",
      "10.1038/nature14182",
      "10.1038/s41586-025-08790-w"
    ],
    "effect_size_source_sentence": "A significant decreasing relationship between connection probability and the difference in preferred orientation was present in more mature V1 but not at eye-opening (P13 – 15, P = 0.27; P22 – 26, P = 0.034, Cochran-Armitage test)."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Significant connection-probability increase with signal correlation at P22–26 (P=4.6×10⁻⁵); not present at P13–15",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-d12ad470ec04"
  ],
  "source_span": "As we reported previously, among responsive L2/3 pyramidal cells, the connection probability increased steeply with increasing signal correlation at P22 – 26.",
  "study_system": "mouse V1 L2/3 pyramidal neurons, in vivo two-photon + ex vivo paired recording, juvenile vs mature",
  "evidence_refs": [
    {
      "ref": "paper:paper-d12ad470ec04"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In vivo two-photon calcium imaging of L2/3 pyramidal responses to gratings at P13–15 and P22–26, followed by multi-electrode patch-clamp paired recordings of the same imaged cells in acute V1 slices; quantification of connection probability vs signal correlation and vs preferred-orientation difference.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}