Version history

{
  "scope": "thalamo-cortical model of PFC interneuron-mediated cognitive flexibility",
  "claim_text": "A circuit model of mediodorsal thalamus and PFC, incorporating PV/SST/VIP interneurons, regulates task uncertainty and supports cognitive flexibility through disinhibitory gating.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_146",
    "doi": "10.1038/s41467-025-58011-1",
    "pmid": "40097445",
    "year": "2025",
    "claim": "A circuit model of mediodorsal thalamus and PFC, incorporating PV/SST/VIP interneurons, regulates task uncertainty and supports cognitive flexibility through disinhibitory gating.",
    "pmcid": "PMC11914509",
    "title": "Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility",
    "authors": "Zhang X, Mukherjee A, Halassa MM, Chen ZS.",
    "journal": "Nature Communications",
    "cite_key": "Zhang2025b",
    "evidence": "Authors developed a thalamo-cortical model of PFC interneuron-mediated cognitive flexibility consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.",
    "vip_role": "attention_topdown",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "thalamo-cortical model of PFC interneuron-mediated cognitive flexibility",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "replicated_independent",
    "_source_cluster_index": 145,
    "claim_source_sentence": "Our model reveals computational mechanisms and geometric interpretations of MD in regulating cue uncertainty and context switching to enable cognitive flexibility.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-2603d6e67df4"
  ],
  "source_span": "Our model reveals computational mechanisms and geometric interpretations of MD in regulating cue uncertainty and context switching to enable cognitive flexibility.",
  "study_system": "thalamo-cortical model of PFC interneuron-mediated cognitive flexibility",
  "evidence_refs": [
    {
      "ref": "paper:paper-2603d6e67df4"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Authors developed a thalamo-cortical model of PFC interneuron-mediated cognitive flexibility consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated_independent",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}