During the delay epoch in mouse ALM, population activity moves toward discrete…

During the delay epoch in mouse ALM, population activity moves toward discrete end points corresponding to specific movement directions; these end points are robust to optogenetic perturbations, and occasional perturbation-induced switches between end points are followed by incorrect actions, consistent with discrete attractor dynamics underlying short-term memory.

{
  "n": 0,
  "doi": "10.1038/s41586-019-0919-7",
  "claim": "During the delay epoch in mouse ALM, population activity moves toward discrete end points corresponding to specific movement directions; these end points are robust to optogenetic perturbations, and occasional perturbation-induced switches between end points are followed by incorrect actions, consistent with discrete attractor dynamics underlying short-term memory.",
  "cite_key": "Inagaki2019",
  "evidence": "Perturbations occasionally switched the population dynamics to the other end point, followed by incorrect actions.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse ALM; intracellular and extracellular electrophysiology with optogenetic perturbations + network modelling",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We show that during the delay epoch, the activity of ALM neurons moved towards discrete end points that correspond to specific movement directions.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature17643",
    "10.1016/j.cell.2021.05.026"
  ],
  "effect_size_source_sentence": "These end points were robust to transient shifts in ALM activity caused by optogenetic perturbations."
}

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  "paper:67bd565b-2a75-461d-9061-05fb0bb877c2"
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    "ref": "paper:67bd565b-2a75-461d-9061-05fb0bb877c2"
  }
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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
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