Lower densities of PV-positive interneurons in caudate and putamen of Tourette…

Details

scope: human postmortem basal ganglia, Tourette syndrome
claim_text: Lower densities of PV-positive interneurons in caudate and putamen of Tourette syndrome subjects, with increased PV+ neurons in GPi, suggesting a developmental migration defect
section_id: section_11_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
effect_size: Markedly higher total neuron number in GPi; lower neuron number and density in GPe and caudate
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-11
source_kind: review_finding
source_path: evidence/section_11_evidence_package.json
source_span: Lower densities of parvalbumin-positive interneurons were observed in both the Cd and putamen of TS subjects.
study_system: human postmortem basal ganglia, Tourette syndrome
section_title: Species Translation, Human Data, and Disease Models
evidence_summary: Stereological analysis of postmortem basal ganglia in Tourette syndrome
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-11
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 5,
  "doi": "10.1073/pnas.0502624102",
  "claim": "Lower densities of PV-positive interneurons in caudate and putamen of Tourette syndrome subjects, with increased PV+ neurons in GPi, suggesting a developmental migration defect",
  "evidence": "Stereological analysis of postmortem basal ganglia in Tourette syndrome",
  "effect_size": "Markedly higher total neuron number in GPi; lower neuron number and density in GPe and caudate",
  "text_access": "fulltext",
  "study_system": "human postmortem basal ganglia, Tourette syndrome",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Lower densities of parvalbumin-positive interneurons were observed in both the Cd and putamen of TS subjects.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "A markedly higher total neuron number was found in the globus pallidus pars interna (GPi) of TS. In contrast, a lower neuron number and density was observed in the globus pallidus pars externa and in the Cd."
}

source_refs

[
  "paper:paper-1ed6118d28b1"
]

evidence_refs

[
  {
    "ref": "paper:paper-1ed6118d28b1"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Lower densities of PV-positive interneurons in caudate and putamen of Tourette…

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