Version history

{
  "scope": "parkinsonian rats, juxtacellular recording-labelling and immunocytochemistry of GPe",
  "claim_text": "The external globus pallidus comprises two distinct neuronal populations — prototypic GABAergic neurons (parvalbumin+, antiphase to STN, targeting downstream BG nuclei) and arkypallidal neurons (preproenkephalin+, in-phase with STN, projecting back to striatum) — establishing a fundamental dichotomy.",
  "raw_fields": {
    "n": 79,
    "doi": "10.1016/j.neuron.2012.04.027",
    "claim": "The external globus pallidus comprises two distinct neuronal populations — prototypic GABAergic neurons (parvalbumin+, antiphase to STN, targeting downstream BG nuclei) and arkypallidal neurons (preproenkephalin+, in-phase with STN, projecting back to striatum) — establishing a fundamental dichotomy.",
    "cite_key": "Mallet2012",
    "evidence": "",
    "effect_size": "prototypic: PV+, antiphase to STN, target BG nuclei; arkypallidal: PPE+, in-phase with STN, target striatum",
    "text_access": "fulltext",
    "study_system": "parkinsonian rats, juxtacellular recording-labelling and immunocytochemistry of GPe",
    "source_cluster_id": "cluster_04",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Preproenkephalin mRNA + cells make up ∼40% of all GPe neurons ( Hoover and Marshall, 2002; Voorn et al., 1999 ), yet large-scale extracellular recordings with low-impedance multielectrode arrays show that GP-TA neurons constitute ∼20% of active GPe units ( Mallet et al., 2008a ).",
    "replication_evidence_dois": [
      "10.1523/jneurosci.4662-14.2015",
      "10.1523/jneurosci.4672-14.2015",
      "10.1016/j.neuron.2015.03.007",
      "10.1016/j.neuron.2015.12.017"
    ],
    "effect_size_source_sentence": "A first population of prototypic GABAergic GPe neurons fire antiphase to subthalamic nucleus (STN) neurons, often express parvalbumin, and target downstream basal ganglia nuclei, including STN."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "effect_size": "prototypic: PV+, antiphase to STN, target BG nuclei; arkypallidal: PPE+, in-phase with STN, target striatum",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-40de7d59349c"
  ],
  "source_span": "Preproenkephalin mRNA + cells make up ∼40% of all GPe neurons ( Hoover and Marshall, 2002; Voorn et al., 1999 ), yet large-scale extracellular recordings with low-impedance multielectrode arrays show that GP-TA neurons constitute ∼20% of active GPe units ( Mallet et al., 2008a ).",
  "study_system": "parkinsonian rats, juxtacellular recording-labelling and immunocytochemistry of GPe",
  "evidence_refs": [
    {
      "ref": "paper:paper-40de7d59349c"
    }
  ],
  "section_title": "Striatal Output Pathways: Direct, Indirect, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}