Version history

{
  "scope": "human",
  "claim_text": "Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy — The therapeutic application of centromedian nucleus stimulation (CMS) has been limited by uncertainties regarding its mechanism of action",
  "raw_fields": {
    "n": 0,
    "doi": "10.1371/journal.pcbi.1012943",
    "claim": "Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy — The therapeutic application of centromedian nucleus stimulation (CMS) has been limited by uncertainties regarding its mechanism of action",
    "title": null,
    "cite_key": "Josephtomy2025",
    "evidence": "Reported in PLoS computational biology (2025); from Body of abstract.",
    "effect_size": "50 Hz",
    "text_access": "abstract_only",
    "study_system": "human",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 323,
    "claim_source_sentence": "The therapeutic application of centromedian nucleus stimulation (CMS) has been limited by uncertainties regarding its mechanism of action.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "These effects were found to be frequency-dependent: while 50 Hz CMS induced no change in neocortical epileptiform activity, CMS at 70 Hz, 100 Hz and 150 Hz led to periods of suppression of neocortical epileptiform activity."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "50 Hz",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-fc48506ce578"
  ],
  "source_span": "The therapeutic application of centromedian nucleus stimulation (CMS) has been limited by uncertainties regarding its mechanism of action.",
  "study_system": "human",
  "evidence_refs": [
    {
      "ref": "paper:paper-fc48506ce578"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Reported in PLoS computational biology (2025); from Body of abstract.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}