Reduced PV interneuron density in mPFC and ventral hippocampus correlates with…

Details

scope: methylazoxymethanol (MAM) rat model of schizophrenia
claim_text: Reduced PV interneuron density in mPFC and ventral hippocampus correlates with reduced gamma-band response during task performance in a schizophrenia model
section_id: section_11_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
effect_size: Decreased PV+ interneuron density in mPFC and ventral subiculum; reduced gamma-band response to conditioned tone
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-11
source_kind: review_finding
source_path: evidence/section_11_evidence_package.json
source_span: MAM-treated rats display a decreased density of parvalbumin-positive interneurons throughout the medial prefrontal cortex (mPFC) and ventral (but not dorsal) subiculum of the hippocampus.
study_system: methylazoxymethanol (MAM) rat model of schizophrenia
section_title: Species Translation, Human Data, and Disease Models
evidence_summary: Electrophysiology in MAM model showing PV loss correlates with gamma deficit
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-11
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1523/jneurosci.5419-08.2009",
  "claim": "Reduced PV interneuron density in mPFC and ventral hippocampus correlates with reduced gamma-band response during task performance in a schizophrenia model",
  "evidence": "Electrophysiology in MAM model showing PV loss correlates with gamma deficit",
  "effect_size": "Decreased PV+ interneuron density in mPFC and ventral subiculum; reduced gamma-band response to conditioned tone",
  "text_access": "abstract_only",
  "study_system": "methylazoxymethanol (MAM) rat model of schizophrenia",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "MAM-treated rats display a decreased density of parvalbumin-positive interneurons throughout the medial prefrontal cortex (mPFC) and ventral (but not dorsal) subiculum of the hippocampus.",
  "replication_evidence_dois": [
    "10.1016/j.biopsych.2015.03.010"
  ],
  "effect_size_source_sentence": "The reduction in interneuron functionality is correlated with a significantly reduced gamma-band response to a conditioned tone during a latent inhibition paradigm."
}

source_refs

[
  "paper:paper-6b9d5ae87be7"
]

evidence_refs

[
  {
    "ref": "paper:paper-6b9d5ae87be7"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Reduced PV interneuron density in mPFC and ventral hippocampus correlates with…

Details

Replication

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