Version history

{
  "scope": "Astrocytes in striatum can regulate dopamine transmission by governing the extracellular tone of axonal neuromodulators, including GABA and adenosine.",
  "claim_text": "We identify that ChI somata are in unexpectedly close proximity to astrocyte somata, in mouse and human, forming a \"soma-to-soma\" satellite-like configuration not typically observed for other striatal neurons.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41467-024-54253-7",
    "claim": "We identify that ChI somata are in unexpectedly close proximity to astrocyte somata, in mouse and human, forming a \"soma-to-soma\" satellite-like configuration not typically observed for other striatal neurons.",
    "cite_key": "Stedehouder2024",
    "evidence": "",
    "effect_size": "20 mV",
    "text_access": "fulltext",
    "study_system": "Astrocytes in striatum can regulate dopamine transmission by governing the extracellular tone of axonal neuromodulators, including GABA and adenosine.",
    "source_cluster_id": "cluster_04",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "These findings show that astrocytes can modulate striatal DA release via buffering of the extracellular neuromodulator environment.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Astrocytes can respond to inputs from local neural networks with dynamic intracellular Ca 2+ signals , (including in striatum), or with membrane depolarizations, by up to ~20 mV , on subsecond timescales (~200–300 ms to ~1 s) in cortical and hippocampal areas , ."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "effect_size": "20 mV",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-023e7ec22e59"
  ],
  "source_span": "These findings show that astrocytes can modulate striatal DA release via buffering of the extracellular neuromodulator environment.",
  "study_system": "Astrocytes in striatum can regulate dopamine transmission by governing the extracellular tone of axonal neuromodulators, including GABA and adenosine.",
  "evidence_refs": [
    {
      "ref": "paper:paper-023e7ec22e59"
    }
  ],
  "section_title": "Striatal Output Pathways: Direct, Indirect, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}