Group I metabotropic glutamate receptors differentially modulate excitatory tra…

Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex — Activation of mGluRs with the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) altered excitatory synaptic efficacy in an interneuron subtype-dependent manner

{
  "n": 0,
  "doi": "10.3389/fnsyn.2026.1766413",
  "claim": "Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex — Activation of mGluRs with the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) altered excitatory synaptic efficacy in an interneuron subtype-dependent manner",
  "title": null,
  "cite_key": "Sandle2026",
  "evidence": "Reported in Frontiers in synaptic neuroscience (2026); from Results of abstract.",
  "effect_size": "3",
  "text_access": "abstract_only",
  "study_system": "rat",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 325,
  "claim_source_sentence": "Activation of mGluRs with the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) altered excitatory synaptic efficacy in an interneuron subtype-dependent manner.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Although their physiological functions and involvement in neurological disorders are well established, direct experimental evidence for their role in human cortical neurons remains limited. [Methods] We investigated the effects of group I mGluR activation on excitatory synaptic transmission in the human supragranular cortex using paired whole-cell patch-clamp recordings from synaptically connected pyramidal cells and interneurons in acute slices of human neocortex resected during neurosurgery. [Results] Activation of mGluRs with the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) altered excitatory synaptic efficacy in an interneuron subtype-dependent manner."
}

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