Version history

{
  "scope": "MPTP-treated rhesus monkeys, extracellular recording from GPe/GPi during STN HFS",
  "claim_text": "Therapeutic high-frequency STN stimulation in MPTP-treated monkeys increased GPe/GPi firing rates and imposed a stimulus-synchronized regular firing pattern, contradicting a simple rate-suppression interpretation of DBS.",
  "raw_fields": {
    "n": 110,
    "doi": "10.1523/jneurosci.23-05-01916.2003",
    "claim": "Therapeutic high-frequency STN stimulation in MPTP-treated monkeys increased GPe/GPi firing rates and imposed a stimulus-synchronized regular firing pattern, contradicting a simple rate-suppression interpretation of DBS.",
    "cite_key": "Hashimoto2003",
    "evidence": "",
    "effect_size": "136 Hz STN HFS → significant increase in mean discharge rate, stimulus-synchronized regular pattern",
    "text_access": "abstract_only",
    "study_system": "MPTP-treated rhesus monkeys, extracellular recording from GPe/GPi during STN HFS",
    "source_cluster_id": "cluster_04",
    "replication_status": "replicated",
    "claim_source_sentence": "These short-latency responses were present with 136 Hz stimulation, at voltages effective for alleviation of parkinsonian signs, resulting in a significant increase in mean discharge rate and a stimulus-synchronized regular firing pattern.",
    "replication_evidence_dois": [
      "10.1056/nejmoa000827",
      "10.1146/annurev.neuro.29.051605.112824"
    ],
    "effect_size_source_sentence": "These short-latency responses were present with 136 Hz stimulation, at voltages effective for alleviation of parkinsonian signs, resulting in a significant increase in mean discharge rate and a stimulus-synchronized regular firing pattern."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "effect_size": "136 Hz STN HFS → significant increase in mean discharge rate, stimulus-synchronized regular pattern",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-f353265a7640"
  ],
  "source_span": "These short-latency responses were present with 136 Hz stimulation, at voltages effective for alleviation of parkinsonian signs, resulting in a significant increase in mean discharge rate and a stimulus-synchronized regular firing pattern.",
  "study_system": "MPTP-treated rhesus monkeys, extracellular recording from GPe/GPi during STN HFS",
  "evidence_refs": [
    {
      "ref": "paper:paper-f353265a7640"
    }
  ],
  "section_title": "Striatal Output Pathways: Direct, Indirect, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}