Anatomical analysis of mouse mPFC pyramidal cells shows most perisomatic GABAer…

Anatomical analysis of mouse mPFC pyramidal cells shows most perisomatic GABAergic axonal varicosities express parvalbumin or cannabinoid-1 receptor (CB1, i.e., cholecystokinin basket cells); the PV/CB1 ratio is larger on pyramidal-tract projection neurons than on contralaterally-projecting cells, and PVBC dendrites/axons arborize within their soma's layer while CCKBC axons span all layers — projection-specific inhibitory microcircuitry that constrains how PFC pyramidals can produce delay-period persistent activity.

{
  "n": 0,
  "doi": "10.1523/jneurosci.0432-23.2023",
  "claim": "Anatomical analysis of mouse mPFC pyramidal cells shows most perisomatic GABAergic axonal varicosities express parvalbumin or cannabinoid-1 receptor (CB1, i.e., cholecystokinin basket cells); the PV/CB1 ratio is larger on pyramidal-tract projection neurons than on contralaterally-projecting cells, and PVBC dendrites/axons arborize within their soma's layer while CCKBC axons span all layers — projection-specific inhibitory microcircuitry that constrains how PFC pyramidals can produce delay-period persistent activity.",
  "cite_key": "NagyPal2023",
  "evidence": "PVBC dendrites and axons arborized preferentially within the layer where their soma was located. In contrast, the axons of CCKBCs expanded throughout layers, although their dendrites were found preferentially either in superficial or deep layers.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse medial prefrontal cortex; cell-type-specific (PV, CB1/CCK) immunolabeling + viral targeting + morphological reconstruction of basket cells onto identified pyramidal projection neurons",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "The ratio of PV/CB1 GABAergic inputs is larger on the somatic membrane surface of pyramidal tract neurons in comparison with those projecting to the contralateral hemisphere.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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PVBC dendrites and axons arborized preferentially within the layer where their soma was located. In contrast, the axons of CCKBCs expanded throughout layers, although their dendrites were found preferentially either in superficial or deep layers.