- claim_text
Persistent representation of motor-planning information in mouse frontal cortex (ALM) depends on the cerebellum: silencing the fastigial nucleus disrupts subsequent correct responses without impairing movement execution, and silencing frontal cortex abolishes cerebellar preparatory activity, defining a closed cortico-cerebellar loop required to maintain cortical preparatory activity.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41586-018-0633-x",
"claim": "Persistent representation of motor-planning information in mouse frontal cortex (ALM) depends on the cerebellum: silencing the fastigial nucleus disrupts subsequent correct responses without impairing movement execution, and silencing frontal cortex abolishes cerebellar preparatory activity, defining a closed cortico-cerebellar loop required to maintain cortical preparatory activity.",
"cite_key": "Gao2018",
"evidence": "",
"effect_size": "",
"text_access": "abstract_only",
"study_system": "mice performing tactile sensory discrimination with short-term memory delay; ALM and cerebellar nuclei recordings + transient optogenetic perturbation",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "A transient perturbation in the medial deep cerebellar nucleus (fastigial nucleus) disrupted subsequent correct responses without hampering movement execution.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1038/s41593-023-01453-x",
"10.1038/nature22324"
],
"effect_size_source_sentence": "The silencing of frontal cortex activity abolished preparatory activity in the cerebellar nuclei, and fastigial activity was necessary to maintain cortical preparatory activity."
}- source_refs
[
"paper:3718cfbc-d86a-4ecc-a5e6-1e0d84e7d205"
]
- evidence_refs
[
{
"ref": "paper:3718cfbc-d86a-4ecc-a5e6-1e0d84e7d205"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}