- claim_text
Neuron-specific expression of murine thyroid hormone transporters Mct8 and Oatp1c1 is dispensable for hippocampus-dependent neuronal functions — Serum TH concentrations and TH-regulated gene expression in the brain were unaltered in both conditional mouse lines
- raw_fields
{
"n": 0,
"doi": "10.3389/fendo.2026.1781214",
"claim": "Neuron-specific expression of murine thyroid hormone transporters Mct8 and Oatp1c1 is dispensable for hippocampus-dependent neuronal functions — Serum TH concentrations and TH-regulated gene expression in the brain were unaltered in both conditional mouse lines",
"title": null,
"cite_key": "Alcaidemartin2026",
"evidence": "Reported in Frontiers in endocrinology (2026); from Results of abstract.",
"effect_size": "8",
"text_access": "abstract_only",
"study_system": "mouse",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "replication_unknown",
"_source_cluster_index": 310,
"claim_source_sentence": "Serum TH concentrations and TH-regulated gene expression in the brain were unaltered in both conditional mouse lines.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "[Introduction] Global absence of the thyroid hormone (TH) transporters monocarboxylate transporter 8 (Mct8) and organic anion transporting polypeptide 1c1 (Oatp1c1) in Mct8/Oatp1c1 double knockout (M/O dKO) mice results in a severe central TH deficit due to impaired TH transport across brain barriers."
}- source_refs
[
"paper:paper-465e8bebe56c"
]
- evidence_refs
[
{
"ref": "paper:paper-465e8bebe56c"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}