Version history

{
  "scope": "mouse ACC long-range projections, miniature endoscopic calcium imaging and optogenetics",
  "claim_text": "Distinct populations of ACC pyramidal neurons project long-range to the periaqueductal gray (PAG) versus the basolateral amygdala (BLA), with ACC-to-PAG projections selectively conveying affective pain information and regulating observational fear in male mice.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41467-025-57230-w",
    "claim": "Distinct populations of ACC pyramidal neurons project long-range to the periaqueductal gray (PAG) versus the basolateral amygdala (BLA), with ACC-to-PAG projections selectively conveying affective pain information and regulating observational fear in male mice.",
    "cite_key": "Choi2025a",
    "evidence": "Circuit-specific calcium imaging and optogenetic manipulations of ACC projection neurons targeting PAG versus BLA in male mice.",
    "effect_size": "",
    "text_access": "abstract_only",
    "study_system": "mouse ACC long-range projections, miniature endoscopic calcium imaging and optogenetics",
    "argument_role": "supporting",
    "replication_status": "novel",
    "claim_source_sentence": "Furthermore, using circuit-specific imaging and optogenetic manipulations, we demonstrate that distinct populations of ACC neurons projecting to the periaqueductal gray (PAG), but not to the basolateral amygdala (BLA), selectively convey affective pain information and regulate observational fear.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": ""
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-9598ac5fa271"
  ],
  "source_span": "Furthermore, using circuit-specific imaging and optogenetic manipulations, we demonstrate that distinct populations of ACC neurons projecting to the periaqueductal gray (PAG), but not to the basolateral amygdala (BLA), selectively convey affective pain information and regulate observational fear.",
  "study_system": "mouse ACC long-range projections, miniature endoscopic calcium imaging and optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-9598ac5fa271"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Circuit-specific calcium imaging and optogenetic manipulations of ACC projection neurons targeting PAG versus BLA in male mice.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "novel",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}