Version history

{
  "scope": "Adolescents with early-onset schizophrenia (n=116) vs matched controls (n=55)",
  "claim_text": "Adolescents with early-onset schizophrenia exhibit increased sensorimotor-thalamic connectivity and decreased prefrontal-cerebello-thalamic connectivity, paralleling the adult-onset thalamic circuit imbalance.",
  "raw_fields": {
    "n": 116,
    "doi": "10.1016/j.jaac.2020.07.903",
    "claim": "Adolescents with early-onset schizophrenia exhibit increased sensorimotor-thalamic connectivity and decreased prefrontal-cerebello-thalamic connectivity, paralleling the adult-onset thalamic circuit imbalance.",
    "cite_key": "Zhang2021b",
    "evidence": "Resting-state fMRI in 116 EOS adolescents (63 drug-naive) and 55 matched HCs using 16 atlas-based thalamic subdivisions.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "Adolescents with early-onset schizophrenia (n=116) vs matched controls (n=55)",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The EOS group showed increased sensorimotor-thalamic connectivity and decreased prefrontal-cerebello-thalamic connectivity, consistent with AOS.",
    "replication_evidence_dois": [
      "10.1016/j.bpsc.2019.04.012",
      "10.1093/schbul/sby166"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-d4c2fe8d33d7"
  ],
  "source_span": "The EOS group showed increased sensorimotor-thalamic connectivity and decreased prefrontal-cerebello-thalamic connectivity, consistent with AOS.",
  "study_system": "Adolescents with early-onset schizophrenia (n=116) vs matched controls (n=55)",
  "evidence_refs": [
    {
      "ref": "paper:paper-d4c2fe8d33d7"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Resting-state fMRI in 116 EOS adolescents (63 drug-naive) and 55 matched HCs using 16 atlas-based thalamic subdivisions.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}