Version history

{
  "scope": "Mouse auditory cortex, awake; optogenetic interneuron manipulation + behavioral frequency discrimination",
  "claim_text": "In mouse auditory cortex, optogenetic suppression or excitation of inhibitory interneurons produces a paradoxical mix of increases and decreases in excitatory firing — consistent with the predictions of strongly coupled E-I recurrent networks operating in the ISN regime — and these neural changes predict behavioral discrimination acuity.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.2457-17.2017",
    "claim": "In mouse auditory cortex, optogenetic suppression or excitation of inhibitory interneurons produces a paradoxical mix of increases and decreases in excitatory firing — consistent with the predictions of strongly coupled E-I recurrent networks operating in the ISN regime — and these neural changes predict behavioral discrimination acuity.",
    "cite_key": "Briguglio2018",
    "evidence": "In vivo extracellular recording + optogenetic PV/SST activation/silencing in awake mouse auditory cortex during tone presentation and a frequency-discrimination task.",
    "effect_size": "paradoxical mix of increases and decreases in excitatory firing rates observed; effect magnitude and sign varied across subjects",
    "text_access": "abstract_only",
    "study_system": "Mouse auditory cortex, awake; optogenetic interneuron manipulation + behavioral frequency discrimination",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "Theoretical studies have predicted that suppression of inhibition in such excitatory-inhibitory networks can lead to either an increase or, paradoxically, a decrease in excitatory neuronal firing, with consequent effects on stimulus selectivity.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We found that, indeed, the effects of optogenetic manipulation on stimulus selectivity and behavior varied in both magnitude and sign across subjects, possibly reflecting differences in circuitry or expression of optogenetic factors."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "paradoxical mix of increases and decreases in excitatory firing rates observed; effect magnitude and sign varied across subjects",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-5150525b71ad"
  ],
  "source_span": "Theoretical studies have predicted that suppression of inhibition in such excitatory-inhibitory networks can lead to either an increase or, paradoxically, a decrease in excitatory neuronal firing, with consequent effects on stimulus selectivity.",
  "study_system": "Mouse auditory cortex, awake; optogenetic interneuron manipulation + behavioral frequency discrimination",
  "evidence_refs": [
    {
      "ref": "paper:paper-5150525b71ad"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In vivo extracellular recording + optogenetic PV/SST activation/silencing in awake mouse auditory cortex during tone presentation and a frequency-discrimination task.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "within_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}