Version history

{
  "scope": "three-population (E-PV-SOM) rate model with analytical stability analysis",
  "claim_text": "In a rate model with E, PV, and SOM populations, paradoxical PV responses to SOM perturbations cannot disambiguate ISN from non-ISN regimes when SOM also targets E cells, complicating optogenetic tests of inhibitory stabilization.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_04",
    "doi": "10.7554/elife.99808",
    "pmid": "40304591",
    "year": "2025",
    "claim": "In a rate model with E, PV, and SOM populations, paradoxical PV responses to SOM perturbations cannot disambiguate ISN from non-ISN regimes when SOM also targets E cells, complicating optogenetic tests of inhibitory stabilization.",
    "pmcid": "PMC12043317",
    "title": "Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.",
    "authors": "Bos H, Miehl C, Oswald AM, Doiron B.",
    "journal": "eLife",
    "cite_key": "Bos2025",
    "evidence": "Mathematical analysis combined with simulation shows paradoxical responses appear in both ISN and non-ISN regimes under realistic SOM→PV and SOM→E connectivity.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "three-population (E-PV-SOM) rate model with analytical stability analysis",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 3,
    "claim_source_sentence": "Thus the observation of paradoxical responses of PV neurons in response to suppression via SOM neurons cannot disclose whether the E neurons operate in the ISN or non-ISN regime if SOM neurons also suppress the activity of E neurons.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_12",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-12-computational-models",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-00de1a2c593e"
  ],
  "source_span": "Thus the observation of paradoxical responses of PV neurons in response to suppression via SOM neurons cannot disclose whether the E neurons operate in the ISN or non-ISN regime if SOM neurons also suppress the activity of E neurons.",
  "study_system": "three-population (E-PV-SOM) rate model with analytical stability analysis",
  "evidence_refs": [
    {
      "ref": "paper:paper-00de1a2c593e"
    }
  ],
  "section_title": "Computational Models of VIP Circuit Function",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Mathematical analysis combined with simulation shows paradoxical responses appear in both ISN and non-ISN regimes under realistic SOM→PV and SOM→E connectivity.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-12-computational-models",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}