- claim_text
The fast-spiking phenotype of cortical interneurons emerges late in postnatal development through coordinated transcriptional regulation of thousands of genes, with upregulation of two-pore K+ leak channels between P10-P25 contributing to mature intrinsic membrane properties.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.0105-09.2009",
"claim": "The fast-spiking phenotype of cortical interneurons emerges late in postnatal development through coordinated transcriptional regulation of thousands of genes, with upregulation of two-pore K+ leak channels between P10-P25 contributing to mature intrinsic membrane properties.",
"evidence": "Whole-genome microarrays and whole-cell patch clamp characterized FS maturation between P7-P40. Two-pore K+ leak channel upregulation contributes to one major difference between immature and adult FS cell membrane properties.",
"effect_size": "thousands of genes with bidirectional transcriptional regulation between P7 and P40",
"text_access": "abstract_only",
"study_system": "mouse neocortical fast-spiking interneurons, P7 to P40",
"replication_status": "independently_replicated",
"claim_source_sentence": "We found that the intrinsic and synaptic physiology of FS cells undergoes profound regulation over the first 4 postnatal weeks and that these changes are correlated with primarily monotonic but bidirectional transcriptional regulation of thousands of genes.",
"replication_evidence_dois": [
"10.1523/jneurosci.2890-08.2008"
],
"effect_size_source_sentence": "these changes are correlated with primarily monotonic but bidirectional transcriptional regulation of thousands of genes belonging to multiple functional classes."
}- source_refs
[
"paper:paper-591943f1ad14"
]
- source_span
We found that the intrinsic and synaptic physiology of FS cells undergoes profound regulation over the first 4 postnatal weeks and that these changes are correlated with primarily monotonic but bidirectional transcriptional regulation of thousands of genes.
- evidence_refs
[
{
"ref": "paper:paper-591943f1ad14"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}