Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses —…

{
  "n": 0,
  "doi": "10.1016/j.neuroimage.2020.117457",
  "claim": "Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses — Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initi",
  "title": null,
  "cite_key": "Poplawsky2021",
  "evidence": "Reported in NeuroImage (2021); from Body of abstract.",
  "effect_size": "1.5 mm",
  "text_access": "abstract_only",
  "study_system": "rat",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 392,
  "claim_source_sentence": "Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initiate functional hyperemia.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "First, to examine if postsynaptic activation of these inhibitory neurons was required for neurovascular coupling, we applied an NMDA receptor antagonist during cerebral blood volume-weighted fMRI acquisition and found that responses below the drug application site (up to ~1.5 mm) significantly decreased within ~30 min."
}

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