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- Live5/17/2026, 4:35:28 PM
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{ "scope": "Mouse motor cortex with retrograde rabies-ChR2 viral tools", "claim_text": "Optogenetics combined with retrograde rabies-virus-encoded ChR2 plus paired recordings demonstrates that corticostriatal and corticospinal projection neurons in layer 5B of mouse motor cortex form recurrent within-class connections (with higher density among corticostriatal than corticospinal neurons), supporting hierarchical, projection-specific local connectivity.", "raw_fields": { "n": 0, "doi": "10.1523/jneurosci.4759-11.2012", "claim": "Optogenetics combined with retrograde rabies-virus-encoded ChR2 plus paired recordings demonstrates that corticostriatal and corticospinal projection neurons in layer 5B of mouse motor cortex form recurrent within-class connections (with higher density among corticostriatal than corticospinal neurons), supporting hierarchical, projection-specific local connectivity.", "cite_key": "Kiritani2012", "evidence": "Retrograde ΔG-rabies-ChR2 + identified-cell paired recordings.", "effect_size": "5", "text_access": "abstract_only", "study_system": "Mouse motor cortex with retrograde rabies-ChR2 viral tools", "source_cluster_id": "cluster_10", "replication_status": "single_study", "claim_source_sentence": "Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connection probability among corticostriatal than among corticospinal neurons.", "replication_evidence_dois": [], "effect_size_source_sentence": "Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connection probability among corticostriatal than among corticospinal neurons." }, "section_id": "section_11", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json", "effect_size": "5", "review_repo": "ComputationalReviewLoops", "section_ref": "wiki_page:computationalreviewloops-11", "source_kind": "review_finding", "source_path": "evidence/section_11_evidence_package.json", "source_refs": [ "paper:paper-e1291622a820" ], "source_span": "Both corticospinal and callosally projecting corticostriatal neurons in layer 5B formed within-class (recurrent) connections, with higher connection probability among corticostriatal than among corticospinal neurons.", "study_system": "Mouse motor cortex with retrograde rabies-ChR2 viral tools", "evidence_refs": [ { "ref": "paper:paper-e1291622a820" } ], "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }, "evidence_summary": "Retrograde ΔG-rabies-ChR2 + identified-cell paired recordings.", "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9", "replication_status": "single_study", "review_package_ref": "analysis_bundle:ab-d49e54403ef9", "source_artifact_ref": "wiki_page:computationalreviewloops-11", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json", "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }