A circuit mechanism modeled with PV, SST, and VIP interneurons enables independ…

{
  "n": null,
  "id": "cluster_11_finding_138",
  "doi": "10.1073/pnas.2116895119",
  "pmid": "35925891",
  "year": "2022",
  "claim": "A circuit mechanism modeled with PV, SST, and VIP interneurons enables independent modulation of excitatory and inhibitory firing rates via VIP-mediated disinhibition.",
  "pmcid": "PMC9371725",
  "title": "A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation",
  "authors": "Richter LMA, Gjorgjieva J.",
  "journal": "Proceedings of the National Academy of Sciences",
  "cite_key": "Richter2022",
  "evidence": "Authors developed a rate model of cortical microcircuit with three interneuron subtypes consistent with the cluster's canonical VIP→SST→pyramidal disinhibitory architecture.",
  "vip_role": "gain_modulation",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "rate model of cortical microcircuit with three interneuron subtypes",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 137,
  "claim_source_sentence": "We find that with a single interneuron subtype (parvalbumin-expressing [PV]), excitatory and inhibitory firing rates can only be comodulated-increased or decreased together.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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]

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}