Details
- scope
- Awake mouse cortex; all-optical large-scale read/write
- claim_text
- All-optical read/write of approximately 10⁴ monitored and 10³ activated neurons across mouse cortical areas — an order-of-magnitude leap over prior capacity — uncovered deep L2/3 SST interneurons resp
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_03_evidence_package.json
- effect_size
- ~10³ optogenetically controlled neurons; ~10⁴ simultaneously monitored neurons (order-of-magnitude over prior)
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-03-paired-recording
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- study_system
- Awake mouse cortex; all-optical large-scale read/write
- section_title
- 3. Paired-recording evidence in mouse — connection probabilities and synaptic strengths between pyramidal cells within a column, layer-by-layer (Lefort, Petersen, Adesnik, Feldmeyer, Markram-style work in mouse)
- evidence_summary
- Direct measurement of the current frontier of all-optical interrogation in mouse cortex, with a finding that bears on cluster_14's synthesis of what large-scale E→E recording supports about wiring rules.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- single-study
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-03-paired-recording
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_03_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- raw_fields
{ "n": 10000, "doi": "10.1101/2025.10.21.683734", "claim": "All-optical read/write of approximately 10⁴ monitored and 10³ activated neurons across mouse cortical areas — an order-of-magnitude leap over prior capacity — uncovered deep L2/3 SST interneurons resp", "cite_key": "Drinnenberg2025", "evidence": "Direct measurement of the current frontier of all-optical interrogation in mouse cortex, with a finding that bears on cluster_14's synthesis of what large-scale E→E recording supports about wiring rules.", "effect_size": "~10³ optogenetically controlled neurons; ~10⁴ simultaneously monitored neurons (order-of-magnitude over prior)", "text_access": "abstract_only", "study_system": "Awake mouse cortex; all-optical large-scale read/write", "argument_role": "supporting", "original_section": "section_16", "replication_status": "single-study", "claim_source_sentence": "[via section_03] Here, we present an all-optical strategy for precise optogenetic activity control of ∼10 3 neurons and simultaneous activity monitoring of ∼10 4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities.", "conflict_context_borrow": true, "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": "Here, we present an all-optical strategy for precise optogenetic activity control of ∼10 3 neurons and simultaneous activity monitoring of ∼10 4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities." }- source_refs
[ "paper:paper-8d923acf5f56" ]
- source_span
[via section_03] Here, we present an all-optical strategy for precise optogenetic activity control of ∼10 3 neurons and simultaneous activity monitoring of ∼10 4 neurons within and across areas of mouse cortex—an order-of-magnitude leap beyond previous capabilities.
- evidence_refs
[ { "ref": "paper:paper-8d923acf5f56" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }