Details
- scope
- mouse somatosensory cortex in vivo, two-photon guided recordings + optogenetics
- claim_text
- Spontaneous thalamic activity drives PV interneuron firing during cortical down states, inhibiting cortex; VPM thalamic activity associated with longer down-state duration in somatosensory cortex
- section_id
- section_10_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- effect_size
- Thalamic muscimol injection reduced PV cell spikes during down states and increased latency of down-to-up transitions
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-10
- source_kind
- review_finding
- source_path
- evidence/section_10_evidence_package.json
- source_span
- These findings demonstrate that spontaneous thalamic activity inhibits cortex during down states through the activation of PV interneurons.
- study_system
- mouse somatosensory cortex in vivo, two-photon guided recordings + optogenetics
- section_title
- Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony
- evidence_summary
- Spontaneous thalamic activity drives PV interneuron firing during cortical down states, inhibiting cortex; VPM thalamic activity associated with longer down-state duration in somatosensory cortex
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-10
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.cub.2019.04.007", "claim": "Spontaneous thalamic activity drives PV interneuron firing during cortical down states, inhibiting cortex; VPM thalamic activity associated with longer down-state duration in somatosensory cortex", "evidence": "Spontaneous thalamic activity drives PV interneuron firing during cortical down states, inhibiting cortex; VPM thalamic activity associated with longer down-state duration in somatosensory cortex", "effect_size": "Thalamic muscimol injection reduced PV cell spikes during down states and increased latency of down-to-up transitions", "text_access": "fulltext", "study_system": "mouse somatosensory cortex in vivo, two-photon guided recordings + optogenetics", "replication_status": "replication_unknown", "claim_source_sentence": "These findings demonstrate that spontaneous thalamic activity inhibits cortex during down states through the activation of PV interneurons.", "replication_evidence_dois": [], "effect_size_source_sentence": "We found increased latency of the optogenetically triggered down-to-up transitions upon thalamic pharmacological blockade compared to controls." }- source_refs
[ "paper:paper-f9dc4fd7408a" ]
- evidence_refs
[ { "ref": "paper:paper-f9dc4fd7408a" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }