In mouse barrel cortex layer 2/3, VIP interneurons are most active during REM s…

In mouse barrel cortex layer 2/3, VIP interneurons are most active during REM sleep, PV cells fire highest during both REM and NREM (with rapid decrease at wake onset), and SST activity is stable across the sleep-wake cycle; PV and most VIP cells are modulated by delta and theta LFP oscillations.

{
  "n": null,
  "doi": "10.1523/jneurosci.1400-21.2022",
  "pmid": "35552234",
  "year": "2022",
  "claim": "In mouse barrel cortex layer 2/3, VIP interneurons are most active during REM sleep, PV cells fire highest during both REM and NREM (with rapid decrease at wake onset), and SST activity is stable across the sleep-wake cycle; PV and most VIP cells are modulated by delta and theta LFP oscillations.",
  "pmcid": "PMC9188387",
  "title": "Vigilance and Behavioral State-Dependent Modulation of Cortical Neuronal Activity throughout the Sleep/Wake Cycle.",
  "authors": "",
  "journal": "",
  "cite_key": "Brecier2022",
  "evidence": "Two-photon Ca2+ imaging + targeted loose-patch/whole-cell recordings + LFP in naturally sleeping head-restrained mice.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "VIP highest during REM; PV highest during REM and NREM; SST stable; PV and SST modulated by delta/theta",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "naturally sleeping head-restrained mice; layer 2/3 primary somatosensory (barrel) cortex",
  "cited_by_count": 28,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 22,
  "claim_source_sentence": "we found that PV action potential firing activity was largest during both rapid eye movement (REM) and nonrapid eye movement (NREM) sleep stages, that VIP neurons were most active during REM sleep, and that the overall activity of SST neurons remained stable throughout the sleep/wake cycle. Simultaneous local field potential (LFP) recordings further revealed that except for SST neurons, a large proportion of neurons were modulated by ongoing delta and theta oscillations.",
  "replication_evidence_dois": [
    "10.1016/j.celrep.2025.116669"
  ],
  "effect_size_source_sentence": "VIP neurons were most active during REM sleep, and that the overall activity of SST neurons remained stable throughout the sleep/wake cycle."
}

[
  "paper:paper-998db42b8f88"
]

we found that PV action potential firing activity was largest during both rapid eye movement (REM) and nonrapid eye movement (NREM) sleep stages, that VIP neurons were most active during REM sleep, and that the overall activity of SST neurons remained stable throughout the sleep/wake cycle. Simultaneous local field potential (LFP) recordings further revealed that except for SST neurons, a large proportion of neurons...

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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