Version history

{
  "scope": "vip-interneurons",
  "claim_text": "Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD) that operates at vasoactive intestinal peptide (VIP) interneuron inputs onto stratum oriens interneurons in the hippocampal CA1 region.<h4>Methods</h4>Whole-cell recordings of oriens interneurons combined with optogenetic VIP-positive input activation in mouse hippocampal slices.<h4>Results</h4>Repeated postsynaptic burst firing alone was sufficient to induce a persistent weakening of VIP-mediated I → I inhibitory transmission onto oriens interneurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1111/apha.70162",
    "pmid": "41549331",
    "tags": [
      "disease_R4"
    ],
    "year": "2026",
    "claim": "Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD) that operates at vasoactive intestinal peptide (VIP) interneuron inputs onto stratum oriens interneurons in the hippocampal CA1 region.<h4>Methods</h4>Whole-cell recordings of oriens interneurons combined with optogenetic VIP-positive input activation in mouse hippocampal slices.<h4>Results</h4>Repeated postsynaptic burst firing alone was sufficient to induce a persistent weakening of VIP-mediated I → I inhibitory transmission onto oriens interneurons.",
    "pmcid": "",
    "round": 4,
    "title": "Non-Hebbian Long-Term Depression at VIP Interneuron Inputs Selectively Tunes Inhibition in Disinhibitory Circuits of Mouse Hippocampus.",
    "authors": "Jabłońska J, Wiera G, Mozrzymas JW.",
    "journal": "",
    "citation": "Jabłońska J, Wiera G, Mozrzymas JW. (2026). . 10.1111/apha.70162",
    "cite_key": "Jabonska2026",
    "effect_size": null,
    "text_access": "abstract_only",
    "citedByCount": 0,
    "isOpenAccess": "N",
    "evidence_type": "in_vivo_function",
    "linked_topics": [
      "arousal_state",
      "sensory_gain",
      "disinhibition_circuit",
      "prediction_novelty",
      "learning_memory",
      "disease_models",
      "hippocampal_VIP",
      "neuropharmacology"
    ],
    "_source_cluster": "cluster_07_in_vivo_function",
    "relevance_score": 14,
    "replication_status": null,
    "_source_cluster_index": 122,
    "claim_source_sentence": "Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD) that operates at vasoactive intestinal peptide (VIP) interneuron inputs onto stratum oriens interneurons in the hippocampal CA1 region.<h4>Methods</h4>Whole-cell recordings of oriens interneurons combined with optogenetic VIP-positive input activation in mouse hippocampal slices.<h4>Results</h4>Repeated postsynaptic burst firing alone was sufficient to induce a persistent weakening of VIP-mediated I → I inhibitory transmission onto oriens interneurons."
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": null,
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  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
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  "source_path": "evidence/section_13_evidence_package.json",
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  "source_span": "Here, we describe a non-Hebbian form of inhibitory long-term depression (iLTD) that operates at vasoactive intestinal peptide (VIP) interneuron inputs onto stratum oriens interneurons in the hippocampal CA1 region.<h4>Methods</h4>Whole-cell recordings of oriens interneurons combined with optogenetic VIP-positive input activation in mouse hippocampal slices.<h4>Results</h4>Repeated postsynaptic burst firing alone was...",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-435d954ea744"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "unevaluated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
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}