Version history

{
  "scope": "mouse SNr, 6-OHDA dopamine depletion model",
  "claim_text": "Chronic dopamine depletion selectively weakens GABAergic direct-pathway control of SNr firing through changes in synaptic decay kinetics, while GPe-SNr inputs (indirect pathway) are unaffected, inverting the normal balance of basal ganglia output.",
  "raw_fields": {
    "n": 142,
    "doi": "10.1016/j.nbd.2024.106512",
    "claim": "Chronic dopamine depletion selectively weakens GABAergic direct-pathway control of SNr firing through changes in synaptic decay kinetics, while GPe-SNr inputs (indirect pathway) are unaffected, inverting the normal balance of basal ganglia output.",
    "cite_key": "Aristieta2024",
    "evidence": "Pathway-specific optogenetic activation in 6-OHDA-lesioned mice + SNr slice and in vivo electrophysiology.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse SNr, 6-OHDA dopamine depletion model",
    "source_cluster_id": "cluster_10",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Using a combination of in vivo and slice electrophysiology, we find that dopamine depletion selectively weakens the direct pathway's influence over neural activity in the SNr due to changes in the decay kinetics of GABA-mediated synaptic currents.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-d55ebc38aa73"
  ],
  "source_span": "Using a combination of in vivo and slice electrophysiology, we find that dopamine depletion selectively weakens the direct pathway's influence over neural activity in the SNr due to changes in the decay kinetics of GABA-mediated synaptic currents.",
  "study_system": "mouse SNr, 6-OHDA dopamine depletion model",
  "evidence_refs": [
    {
      "ref": "paper:paper-d55ebc38aa73"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Pathway-specific optogenetic activation in 6-OHDA-lesioned mice + SNr slice and in vivo electrophysiology.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}