Details
- scope
- Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers.
- claim_text
- [Inhibitory circuit motifs of cortical somatosensor] This tactile information is processed in the whisker region of the primary somatosensory cortex (wS1), also called barrel cortex (Woolsey & Van der Loos,).
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_03_evidence_package.json
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-03-paired-recording
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- This tactile information is processed in the whisker region of the primary somatosensory cortex (wS1), also called barrel cortex (Woolsey & Van der Loos,).
- study_system
- Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers.
- section_title
- 3. Paired-recording evidence in mouse — connection probabilities and synaptic strengths between pyramidal cells within a column, layer-by-layer (Lefort, Petersen, Adesnik, Feldmeyer, Markram-style work in mouse)
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- unevaluated
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-03-paired-recording
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_03_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- raw_fields
{ "n": null, "doi": "10.1113/jp288309", "claim": "[Inhibitory circuit motifs of cortical somatosensor] This tactile information is processed in the whisker region of the primary somatosensory cortex (wS1), also called barrel cortex (Woolsey & Van der Loos,).", "cite_key": "Preuss2026", "evidence": "Layer (L) 5 is a hub in the cortical column in which a multitude of feedforward and feedback pathways converge. These inputs are then transmitted to distant sites by resident pyramidal neurons (PN). L5 PN are under the strong influence of local somatostatin (SST)-expressing interneurons (IN). To better understand the inhibitory control of L5 SST cells, which leads to disinhibition of excitatory cells, we used paired whole-cell patch-clamp recordings in acute brain slices. We investigated whether they receive intra- and translaminar inputs by parvalbumin (PV) and vasoactive intestinal polypeptide (VIP) IN and what type of short-term synaptic plasticity these inputs display. In triple transgenic mice we found that intralaminarly both PV and VIP IN effectively target L5 SST IN. PV to SST connections were depressing at all tested frequencies, whereas VIP to SST connections were facilitating at high-frequency VIP IN stimulation. In addition translaminar inputs from L2/3 VIP to L5 SST IN showed similar connectivity rates and short-term plasticity compared to their L5 counterparts. However L2/3 PV IN, despite numerous descending axon collaterals, showed hardl", "effect_size": null, "text_access": "fulltext", "study_system": "Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers.", "argument_role": "supporting", "replication_status": null, "claim_source_sentence": "This tactile information is processed in the whisker region of the primary somatosensory cortex (wS1), also called barrel cortex (Woolsey & Van der Loos,).", "source_provenance_status": "ok", "replication_evidence_dois": [], "claim_rewritten_from_source": true, "effect_size_source_sentence": null }- source_refs
[ "paper:paper-737e539c1091" ]
- evidence_refs
[ { "ref": "paper:paper-737e539c1091" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }- evidence_summary
Layer (L) 5 is a hub in the cortical column in which a multitude of feedforward and feedback pathways converge. These inputs are then transmitted to distant sites by resident pyramidal neurons (PN). L5 PN are under the strong influence of local somatostatin (SST)-expressing interneurons (IN). To better understand the inhibitory control of L5 SST cells, which leads to disinhibition of excitatory cells, we used paired whole-cell patch-clamp recordings in acute brain slices. We investigated whether they receive intra- and translaminar inputs by parvalbumin (PV) and vasoactive intestinal polypeptide (VIP) IN and what type of short-term synaptic plasticity these inputs display. In triple transgenic mice we found that intralaminarly both PV and VIP IN effectively target L5 SST IN. PV to SST connections were depressing at all tested frequencies, whereas VIP to SST connections were facilitating at high-frequency VIP IN stimulation. In addition translaminar inputs from L2/3 VIP to L5 SST IN showed similar connectivity rates and short-term plasticity compared to their L5 counterparts. However L2/3 PV IN, despite numerous descending axon collaterals, showed hardl